The Holy Spirit Prayer Center is a public charity that directly benefits the poor and distressed, throughout the world, especially children, who are; living in a rural area, living in a metropolitan area, living in a natural disaster area, or living in a war torn area.

Denise Calabrese (Foundress), President & CEO of the Holy Spirit Prayer Center is a Liturgical Minister and certified Master Catechist of Faith Education. Denise concurrently holds the office of Media Apostolate, which is answering the call of Saint John Paul II for a New Evangelization. It focuses on St. John Paul II's, Christifideles Laici and Vatican II's, decree on the Apostolate of the Laity.

The United States Conference of Catholic Bishops (USCCB) declared that “New Evangelization calls each of us to deepen our faith, believe in the Gospel message and go forth to proclaim the Gospel. The focus of the New Evangelization calls all Catholics to be evangelized and then go forth to evangelize. In a special way, the New Evangelization is focused on 're-proposing' the Gospel to those who have experienced a crisis of faith. Pope Benedict XVI called for the re-proposing of the Gospel 'to those regions awaiting the first evangelization and to those regions where the roots of Christianity are deep but who have experienced a serious crisis of faith due to secularization.' The New Evangelization invites each Catholic to renew their relationship with Jesus Christ and his Church."

The USCCB states, “Evangelization always includes loving our neighbor and working to uphold his or her dignity. Echoing the Gospels, Pope Benedict XVI writes in Deus Caritas Est (God is Love), Love of God and love of neighbor have become one; in the least of the brethren we find Jesus himself, and in Jesus we find God (no. 15).”